Building Blocks of Nanotechology
Buckyballs, Nanotubes, DNA, and Micromachines: Building Blocks of NanotechNanotechnology is a field that’s just being established, and although there are big plans for the smallest of technologies, right now, most of what nanotechnologists have accomplished falls into three categories: new materials—usually chemicals—made by assembling atoms in new ways; new tools to make those materials; and the beginnings of tiny molecular machines.
The development of tools such as AFMs coincided with the introduction of very powerful new computers and software that scientists could use to simulate and visualize chemical reactions or “build” virtual atoms and molecules. This was especially useful for scientists working with complex chemical molecules, particularly DNA. Researchers recognized that the actions of DNA resembled some of the things nanotechnologists were now calling for—the use of molecules to construct other molecules, the self-replication of molecules, and the use of molecule-size mechanical devices. Perhaps DNA (or its cousin, RNA) could be modified to create the first nanomachines?
Geneticists had already found ways to use DNA taken from bacteria to make a nano-scale replicator used for scientific research. By modifying some of the chemical reactions that take place in natural DNA, genetic engineers had figured out a way to make copies of nearly any DNA molecule they wanted to study. But with the computers and tools available to them by the 1990s, they began using DNA or DNA-like molecules to do other things—like construct new chemicals or tiny machines. Many researchers began investigating ways to make proteins—the components from which DNA is made—that would perform useful tasks, such as interacting with other materials or living cells to create new materials or perhaps attack diseases. One of the first breakthroughs was Professor Nadrian Seeman’s demonstration of a tiny “robot arm” made from modified DNA. While the arm could not yet really do anything useful, it did demonstrate the concept.
Meanwhile, electronics researchers approached nanotechnology from another direction. Since 1959, engineers had etched and coated silicon chips using a variety of processes to make integrated circuits (ICs). The transistors and other chip elements reached nano-scale in the late 1990s. They also used these same techniques to develop the first micromachines—microscopic devices with actual moving parts. Some of the early versions of these were simply intended to demonstrate the process without doing anything particularly useful, such as a tiny guitar with a string that could be plucked using an atomic force microscope. But in the late 1980s these began to be commercialized as machines-on-a-chip, or micro-electrco-mechanical systems (MEMs), which combine ICs and tiny mechanical elements. However useful MEMs are, most engineers feel that the techniques used to make ordinary ICs will never be refined enough to make true nanotechnologies. For that reason, engineers are now concentrating on discovering entirely new ways to make ICs, building them from the ground up rather than cutting and etching “bulk” silicon slices.
With the appearance of protein-based chemistry and other techniques in the 1990s, researchers began looking both for practical uses for nanotechnology and new ways to make nano-molecules or micromachines. A different but related problem was that of making nanomolecules in large numbers. A single nanomachine or nanocircuit for example, would not be able to do enough work to make a difference in the real world—thousands or millions might be needed. Engineers needed ways to turn out their nanomachines in huge numbers, and so they began looking for a way to make a nano-scale machine or molecule that would assemble other nano-scale machines or molecules. K. Eric Drexler called it a “self assembler,” and scientists believe that it will be one of the keys to making certain kinds of nanotechnology useful and practical. To date, very few practical nanotechnologies and no self-assemblers have been used outside the laboratory.